Here are some contradicted combinations of drugs in modern medicine that every doctor should know and avoid giving to patients.
Greetings Doctors, I am Dr.Himanshu Jha. In this article, we will explore some of the contraindicated combinations of drugs in modern medicine that every doctor should know and avoid prescribing to patients.
As you may recall, in our previous article, we discussed the topic “BAMS Duty Doctor Job Interview: What Salary to Expect and How to Prepare?” If you have not read that article yet, you can find it on Ayurveda Siddhi.
Today’s topic is “Contraindications of Drugs”. In Ayurveda, we have the concept of Virudh Aahara (Incompatible food) that can cause adverse effects on the body. Similarly, in allopathy, we have the concept of Virudh Ausadh (Incompatible drugs) that can cause harmful interactions when taken together. These drug combinations should be avoided by doctors. In this article, I will explain why these combinations are dangerous and what symptoms they can cause.
| Don’t give | with | Because (Reason) |
|---|---|---|
| Tetracyclines | Penicillins | tetracyclines are bacteriostatic and inhibit the growth of bacteria and penicillins work only on actively dividing organisms. |
| Azithromycin | Antihistamines | severe chest pain and prolong QT interval |
| Anti-acid or anti-ulcer medication | Iron in pt. with IDA | iron needs acidic media to be absorbed. |
| Metronidazole | Warfarin | Metronidazole inhibits the metabolism of warfarin by blocking (CYP-2C9) which may lead to fatal bleeding |
| furosemide (lasix) | Gentamycin | maybe lead to hearing loss |
| Non-dihydropyridine (Verapamil & diltiazem) | Beta-blocker | both of them cause Severe bradycardia & heart block |
| Nifedipine or any drug ending with “dipine” | Nitrate | both of them cause vasodilation & Severe hypotension |
| Sildenafil (Viagra) | Sublingual nitroglycerin | both of them cause vasodilation –> Severe hypotension & may be death |
| Omega 3 | Antiplatelet or Anticoagulant | Because it causes bleeding |
| Statin | Gemfibrozil | increase the risk of the myopathy |
| Ciprofloxacin, Clarithromycin, Cimitidine, Fluvoxamine & erythromycin | theophylline | these drugs are Cyp450 inhibitors that lead to inc. in the theophylline level in the blood leading to death |
| Warfarin | NSAIDS | increase the risk of the GIT bleeding |
| Omperaszole | Clopidogrel (Antiplatelet) | Omeprazole decreases the effect of the clopidogrel by affecting the hepatic enzyme CYP2C19 metabolism |
| K_ sparing diuretics ( amiloride & Spironolactone ) | ACEI ( captopril ) | lead to hyperkalemia |
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