Dangerous Drug Combinations: What Every Doctor Should Know

Here are some contradicted combinations of drugs in modern medicine that every doctor should know and avoid giving to patients. […]

Here are some contradicted combinations of drugs in modern medicine that every doctor should know and avoid giving to patients.

Greetings Doctors, I am Dr.Himanshu Jha. In this article, we will explore some of the contraindicated combinations of drugs in modern medicine that every doctor should know and avoid prescribing to patients.

As you may recall, in our previous article, we discussed the topic “BAMS Duty Doctor Job Interview: What Salary to Expect and How to Prepare?” If you have not read that article yet, you can find it on Ayurveda Siddhi.

Today’s topic is “Contraindications of Drugs”. In Ayurveda, we have the concept of Virudh Aahara (Incompatible food) that can cause adverse effects on the body. Similarly, in allopathy, we have the concept of Virudh Ausadh (Incompatible drugs) that can cause harmful interactions when taken together. These drug combinations should be avoided by doctors. In this article, I will explain why these combinations are dangerous and what symptoms they can cause.

Don’t givewithBecause (Reason)
TetracyclinesPenicillinstetracyclines are bacteriostatic and inhibit the growth of bacteria and penicillins work only on actively dividing organisms.
AzithromycinAntihistaminessevere chest pain and prolong QT interval
Anti-acid or anti-ulcer medicationIron in pt. with IDAiron needs acidic media to be absorbed.
MetronidazoleWarfarinMetronidazole inhibits the metabolism of warfarin by blocking (CYP-2C9) which may lead to fatal bleeding
furosemide (lasix)Gentamycinmaybe lead to hearing loss
Non-dihydropyridine (Verapamil & diltiazem)Beta-blockerboth of them cause Severe bradycardia & heart block
Nifedipine or any drug ending with “dipine”Nitrateboth of them cause vasodilation & Severe hypotension
Sildenafil (Viagra)Sublingual nitroglycerinboth of them cause vasodilation –> Severe hypotension & may be death
Omega 3Antiplatelet or AnticoagulantBecause it causes bleeding
StatinGemfibrozilincrease the risk of the myopathy
Ciprofloxacin, Clarithromycin, Cimitidine, Fluvoxamine & erythromycintheophyllinethese drugs are Cyp450 inhibitors that lead to inc. in the theophylline level in the blood leading to death
WarfarinNSAIDSincrease the risk of the GIT bleeding
OmperaszoleClopidogrel (Antiplatelet)Omeprazole decreases the effect of the clopidogrel by affecting the hepatic enzyme CYP2C19 metabolism
K_ sparing diuretics ( amiloride & Spironolactone )ACEI ( captopril )lead to hyperkalemia

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